Insights into the role of DNA repair and Huntington's disease gene mutation open new avenues for drug discovery

(IOS Press) DNA repair is an important factor that determines how early or late Huntington's disease (HD) occurs in individuals who carry the expanded CAG repeat in the HTT gene that causes HD. This special issue of the Journal of Huntington's Disease is a compendium of new reviews on topics ranging from the discovery of somatic CAG repeat expansion in HD, to our current understanding of the molecular mechanisms involved and the development of potential new therapies targeting these mechanisms.